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They met during Desmond's Time Traveling flashbacks in the season 3 episode "Flashes Before Your Eyes." Eloise is a ring saleswoman and Desmond is trying to buy a ring for Penny, and tells Desmond that he cannot change his destiny.

>>>>>Actually she knew him from her sons' journal after she killed him on the island in 1977. In his journal he wrote that Desmond would be his constant.

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