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Broadly it seems Jacob and the Nemesis are stuck in some sort of (possibly eternal) battle. Neither can kill the other. The nemesis refers to trying to find a loophole in the 'rules' (whatever they are and however they came to be) that allows him to win.

Until S6, your guess is as good as ours.

http://lostpedia.wikia.com/wiki/Jacob%27s_nemesis/Theories

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